Apr 16, 12:00 PM: Poul Nissen, PhD, Aarhus University, Denmark, âStructure and dynamics of ...
Active transport plays a major role in cells. In brain, Na,K-ATPase activity alone accounts for an estimated 40-70% of ATP hydrolysis. Also Ca2+-ATPases of the same P-type ATPase family contribute critically to ion homeostasis in all cell types. These activities are fundamental to life, and malfunction is linked to a range of disorders such as neurological and cardiovascular diseases. Using primarily membrane protein crystallography combined with biochemical and electrophysiological studies, single-molecule FRET, molecular dynamics simulations, modelling, & in vivo models, we have contributed to our growing insight into the mechanistic concepts and functional cycle of the mammalian Na,K-ATPase and Ca2+-ATPase ion pumps. Recently we have also initiated cryoEM studies supported by a large Danish-Swedish cryoEM network, and defined rationales for new X-ray and neutron scattering studies based on the emerging facilities at the MAX IV synchrotron and European Spallation Source in Lund and the European XFEL and Petra3 X-ray sources in Hamburg. Hosted by Benoit Roux and Eduardo PerozoDate: April 16, 2018Time: 12:00 PM - 1:00 PM