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| Born Moscow, Russia, 1971. |
| Moscow State University, Diploma, 1993. |
| University of Chicago, Ph.D., 1998. |
| University of Pennsylvania, Postdoctoral Associate, 1998-2000. |
| University of Chicago, Assistant Professor, 2000-2006. |
| University of Chicago, Associate Professor, 2006-present. |
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| Accolades |
| 2006 SSOCJ Lectureship Award, Japan. |
| 2005 National Science Foundation CAREER Award. |
| 2005 GlaxoSmithKline Chemistry Scholar Award. |
| 2004 Camille Dreyfus Teacher-Scholar Award. |
| 2004 Amgen Young Investigator's Award. |
| 2004 American Cancer Society Research Scholar. |
| 2003 Alfred P. Sloan Fellow. |
| 1997 Elizabeth R. Norton Prize for Excellence in Graduate Research. |
| 1993 Diploma with Honors, Moscow State University. |
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| Sergey A. Kozmin |
| Associate Professor |
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| Research Interests: |
| Chemical synthesis plays an increasingly significant role in the advancement of life sciences. Our research program aims to advance this important paradigm. The main emphasis is on invention of new catalytic reactions, practical assembly of complex bioactive natural products, and efficient generation of highly diverse chemical libraries. The parallel objective is to bring together organic synthesis, cell biology and biochemistry in order to enable the development of an arsenal of new small-molecule agents for basic and translational biomedical research.
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| Catalysis of new carbon-carbon bond-forming reactions is of central importance in organic synthesis. We are developing a series of new catalytic processes that exploit unique reactivity of highly electron rich alkynes. Depicted below is a recently discovered Au-catalyzed skeletal reorganization of acyclic siloxy enynes to siloxy cyclohexadienes, which proceeds according to a highly unusual mechanism involving a series of 1,2-alkyl shifts. |
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| Natural products serve as a foundation for many pharmaceutical agents and enable dissection of important biological pathways, validation of therapeutic targets, and invention of new synthetic methods. We are developing practical synthetic approaches to complex bioactive natural products, and using our synthetic expertise to establish the mode of action of these agents at the cellular and molecular levels. A representative example of our work in this area is shown below. We have designed and executed a 15-step synthesis of bistramide A, revised previously suggested mode of action, and established actin as the primary cellular receptor of this highly potent antiproliferative natural product. |
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| Chemical libraries represent a valuable resource for drug discovery. However, parallel synthesis of highly diverse chemical libraries has revealed many significant challenges. Our laboratory is engaged in the development of an arsenal of new methods, concepts and strategies designed to increase the efficiency of the assembly of new small-molecule libraries. Synthesis of chemical libraries is closely integrated with high-throughput screening to identify new agents capable of potent and specific regulation of proteins in complex living systems. |
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| Selected References |
| Zhang, L.; Sun, J.; Kozmin S. A. Gold and Platinum Catalysis of Enyne Cycloisomerization. Adv. Synth. Catal. (Special Issue), 2006, 348, in press. |
| Sun, J.; Conley, M.; Zhang, L.; Kozmin, S. A. Gold and Platinum-Catalyzed Cycloisomerizations of 1,5-Enynes to Cyclohexadienes with a Broad Alkyne Scope. J. Am. Chem. Soc. 2006, 128, 9705-9710. |
| Sun, J.; Kozmin, S. A. Silver-Catalyzed Hydroamination of Siloxy Alkynes. Angew. Chem. Int. Ed. 2006, 45, 4991-4993. |
| Rizvi, S.; Tereshko, V.; Kossiakoff, A. A.; Kozmin, S. A. Structure of Actin-Bistramide A Complex at 1.35 Å Resolution. J. Am. Chem. Soc. 2006, 128, 3882-3883. |
| Statsuk, A. V.; Bai, R.; Baryza, J. L.; Verma, V. A.; Hamel, E.; Wender, P. A.; Kozmin, S. A. Actin is the Primary Cellular Receptor of Bistramide A. Nature Chem. Biol. 2005, 1, 383-388. |
| Sun, J.; Kozmin, S. A. Brønsted Acid-Promoted Cyclizations of 1-Siloxy-1,5-Diynes. J. Am. Chem. Soc. 2005, 127, 13512-13513. |
| Zhang, L.; Kozmin, S. A. Gold-Catalyzed Assembly of Heterobicyclic Systems. J. Am. Chem. Soc. 2005, 127, 6962-6963. |
| Zhang, L.; Kozmin, S. A. Gold-Catalyzed Cycloisomerizations of Siloxy
Enynes to Cyclohexadienes. J. Am. Chem. Soc. 2004, 126, 11806-11807. |
| Zhang, L.; Kozmin, S. A. Brønsted Acid-Promoted Cyclizations of Siloxyalkynes with Arenes and Alkens. J. Am. Chem. Soc. 2004, 126, 10204-10205. |
| Statsuk, A. V.; Liu, D.; Kozmin, S. A. Synthesis of Bistramide A. J. Am. Chem. Soc. 2004, 126, 9546-9547 |
| Sweis, R.; Schramm, M. P.; Kozmin, S. A. Silver-Catalyzed [2+2] Cycloadditions of Siloxyalkynes. J. Am. Chem. Soc. 2004, 126, 7442-7443. |
| Kozmin, S. A., Wang,
Y. A Three-Dimensional Array for Multiparallel Synthesis.
Angew. Chem. Int. Ed. 2003, 42,
903-905. |
| Wang, Y.; Janjic, J.;
Kozmin, S. A. Synthesis of Leucascandrolide A via a Spontaneous Macrolactolization.
J. Am. Chem. Soc. 2002,124, 13670-13671. |
| Schramm, M. P., Reddy,
D. S.; Kozmin, S. A. Siloxyalkyne-Alkene Metathesis: Rapid Access to Highly
Functionalized Enones. Angew. Chem. Int. Ed.
2001, 40, 4274-4277. |
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Organic Chemistry 